Michelin 285/45/22
Just put a set of Michelin Defender XLT M/S on my 2013 Qx56, the defender is the replacement for the M/S2, I have owned 6 sets of M/S2 on multiple vehicles and have never got less than 70,000 miles out of them.
We just go hammered with Ice and snow here and they have performed great, ride is improved, shift points seem unchanged.
I will update as I put miles on them.